Incidence:  More than 12,000 people in the U.S. have a definite diagnosis of ALS, for a prevalence of 3.9 cases per 100,000 persons in

the U.S. general population.

NIH Fact sheet ALS

Medical Cannabis Indication:   Amyotrophic Lateral Sclerosis (ALS)

          Improves:    Neuropathic Pain, Quality of sleep, Muscle Relaxation, 

                              Akinesia (impairment of voluntary movements), Bronchodilation,

                              Saliva reduction, Appetite stimulation

Recommended cannabinoid ratios:  

                     equal ratio THC: CBD (e.g. 1:1) 

                     high THC : low CBD (e.g. 20:1)


Go slow and start dosing low and titrate until desired results are achieved.

 (Combination of  the above products may be required).  THC doses greater than 10mg/dose not recommended


Neuroprotective properties may slow progression of disease.

Cannabinoid replacement therapy may reduce symptoms and prolong survival. 

(Please note that cannabinoid therapy is patient specific and may require dose/concentration adjustment. Please consult with your provider for appropriate therapy options.)


Journal Articles:

Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease (Review) 

Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses (abstract only)