Incidence:  More than 12,000 people in the U.S. have a definite diagnosis of ALS, for a prevalence of 3.9 cases per 100,000 persons in

the U.S. general population.

NIH Fact sheet ALS

Medical Cannabis Indication:   Amyotrophic Lateral Sclerosis (ALS)

          Improves:    Neuropathic Pain, Quality of sleep, Muscle Relaxation, 

                              Akinesia (impairment of voluntary movements), Bronchodilation,

                              Saliva reduction, Appetite stimulation

Recommended cannabinoid ratios:  

                     equal ratio THC: CBD (e.g. 1:1) 

                     high THC : low CBD (e.g. 20:1)

Dosing:  

Go slow and start dosing low and titrate until desired results are achieved.

 (Combination of  the above products may be required).  THC doses greater than 10mg/dose not recommended

Other:  

Neuroprotective properties may slow progression of disease.

Cannabinoid replacement therapy may reduce symptoms and prolong survival. 

(Please note that cannabinoid therapy is patient specific and may require dose/concentration adjustment. Please consult with your provider for appropriate therapy options.)

References: 

Journal Articles:

Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease (Review) 

Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses (abstract only)